PROGESTERONE SUPPOSITORIES

Many pharmacies use a PEG (polyethylene glycol) base, because it melts at a slightly higher temperature. Since most pharmacies do not have the capability to seal the suppositories in a leakproof plastic shell, the higher melting point gives them a bit more room in dispensing the suppositories in warm weather. However, the PEG base is much, much harsher, and almost universally causes diarrhea, gas, cramping, bloating etc. PEG also does not always dissolve fully, and breaks very easily. The other base that is available is called a fatty acid base (FA), and although it melts at a lower temperature, it can be much less problematic for you. It is a specially fractionated fatty acid derivative, and does not cause the reactions that are typical for the PEG base. However, unless one has the capability to make and seal the finished suppository in a plastic shell, you cannot compound with the FA base, since it melts easily in warm weather. As a PCAB accredited compounding pharmacy, we use ONLY the FA base unless the physician specifically requests a PEG base.  In addition, the use of a sealed plastic shell is clean and hygienic, since the suppository itself is never handled by the pharmacist, and it remains sealed until you open the shell at the time of use.

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