QDots to Treat Oral Thrush

Oral Thrush is a yeast infection caused by the yeast fungus Candida albicans. It causes painful ulcers and lesions in the mouth which have a white color and apear to be raised patches. Oral Thrush is most commonly treated with  antifungal medications such as nystatin, clotrimazole, and miconazole They are administered in the mouth (swallowing the medicine after "swishing" it around). The pain from the infection often will make taking medication difficult for the patient and compliancy can become an issue. We can compound nystatin into a Qdot, which is a rapidly dissolving flavored tablet that is placed in the mouth. It makes the medication palatable and much easier to administer to someone with oral pain, such as child who will not hold liquid in their mouth. For more information on compounded dosage forms of nystatin for oral thrush, please contact us.

Clinical evaluation of a nystatin pastille for treatment of denture-related oral candidiasis.
Johnson GH, Taylor TD, Heid DW.
University of Washington, School of Dentistry, Seattle.

Nystatin has been formulated in the form of a flavored pastille (troche) as an alternative to the oral suspension. This parallel, double-blind, randomized, placebo-controlled study evaluated the acceptance and effectiveness of the nystatin pastille at two different dosages. Twenty-four subjects were selected on the basis of clinical signs of denture stomatitis and culture isolation of Candida spp. Each subject was randomly assigned to one of three treatment groups (A, 200,000 units; B, 400,000 units; and C, placebo). At entry, 7 days, 14 days, and at 10 days after cessation of treatment, the clinical condition was evaluated and Gram stain smears and imprint cultures were made and analyzed. The flavored pastille was well accepted by the subjects and both dosages were shown to be effective in significantly reducing or eliminating the Candida organism during active therapy. Data from the 10-day follow-up, however, demonstrated reinfection with the organism. Thus to resolve the condition, effective therapy must include treatment of the etiologic factors of denture stomatitis along with antimicrobial therapy.

Source: PMID: 2657027 [PubMed - indexed for MEDLINE]; Journal of  Prosthet Dent. 1989 Jun;61(6):699-703. http://www.nlm.nih.gov